Semax Nasal Spray For Sale

• 50 mg (15 ml)
• Next-day UK delivery
• International shipping is available
• May improve cognitive function
• May alleviate anxiety and depression
• May improve recovery from spinal cord injury

Semax is a synthetic heptapeptide that contains amino acids 4-7 from the hormone ACTH and an additional Pro-Gly-Pro sequence at the C-terminal to enhance stability. Although it is derived from ACTH, which promotes the release of cortisol, Semax does not have the same downstream hormonal effects. It is primarily known for its beneficial effects on the brain.

Mechanism of action

It acts as a nootropic, neurotrophic, and neuroprotective agent by:

• Increasing BDNF protein: The synthesis of BDNF is increased in the forebrain of rats. Here, it is able to modulate synaptic plasticity.¹
• Suppressing the expression of inflammatory genes: It can significantly reduce the expression of the pro-inflammatory cytokines Il1a, Il1b, Il6, Ccl3, and Cxcl2.²
• Modulates the expression of immune-related genes: The expression of both chemokines and immunoglobulins was altered within hours of Semax administration.³
• Prevents decline in the expression of genes related to neurotransmission: Genes involved in neurotransmission are activated soon after administration.⁴
• Potentiates dopamine and serotonergic transmission: It modulates the serotonergic system and increases the release of dopamine in rodents.⁵
• Promotes the survival of neurons under stress: Neurons challenged by oxidative stress are less likely to suffer damage when treated with Semax.⁶

Therapeutic potential

This broad range of effects that Semax confers to the brain means that it has the potential to improve brain health, recovery, and cognition. It has been investigated in the following areas:

• Therapy for ischemic stroke: In animal models, it can improve functional and motor recovery, as well as improve cognitive deficits caused by cerebral ischemia.^7,8 This is thought to be due to its ability to enhance cell survival and reduce inflammation.
• Cognitive impairment and dementia: Semax helps to prevent the formation of Aβ:Cu²⁺ complexes and can prevent aggregates from forming in vitro.⁹ Animal experiments have found that it can enhance memory and attention.¹⁰
• Anxiety and depression: Animal tests have suggested that chronic administration of Semax may reduce anxiety and depression.^10,11
• Spinal cord injury: It improved functional recovery and reduced oxidative stress in animal models of spinal cord injury.¹²

Semax has demonstrated a wide range of beneficial effects on the brain, most of which have been investigated in vitro and with the help of animal models.

Safety

Semax has been tested on humans in doses of up to 18 mg per day in addition to conventional stroke therapy, where it has been beneficial to recovery.^13,14 It has also been administered in doses of 12 mg per day, intranasally, for a total of 20 days to patients suffering from motor neuron disease, where it improved quality of life¹⁵ and has been used to improve optic nerve disease.¹⁶

Most clinical studies have been short but have revealed no adverse reactions, low toxicity, and high tolerability.

High doses of alcohol in rats were found to increase the intensity of cravings for alcohol, and the administration of Semax did not mitigate this.¹⁷

How it compares to Selank

Both Semax and Selank are synthetic neuropeptides, but they differ in the following ways:

• Origin: Semax is derived from the ACTH hormone. Although ACTH signals to the adrenal glands to produce cortisol, a hormone that regulates the body’s response to stress, Semax does not trigger this same hormonal response. Selank is an extended version of an immunomodulatory peptide called tuftsin.
• Mechanism: Semax works mainly through the stimulation of BDNF, immunomodulatory activity, cell survival, and the potentiation of dopamine and serotonin. Selank works by modulating GABAergic pathways, influencing monoamine neurotransmitters, and increasing BDNF.
• Research focus: Research on Semax has focused mainly on its ability to mitigate neuronal damage and increase cognition. Selank has been studied for its anxiolytic effect.

Data sheet

Application	Research on neurotrophy, neuroprotection, and cognitive enhancement
CAS Number	80714-61-0
Molecular Weight (g/mol)	813.92
Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Chemical Formula	C37H51N9O10S
Synonyms	ACTH(4–7) Pro-Gly-Pro, MEHFPGP
Storage	Keep refrigerated at 2–8°C until use. For long-term storage, keep at -20°C.
Form	Nasal Spray

Conclusion

Semax has been found to exert several beneficial effects on the brain, mitigating damage and improving cognition. So far, animal and human studies have found that it produces statistically significant improvements with high tolerability.